Can I use IRIS Clarity with an audio recording and a calling platform at the same time?

Neither Windows nor macOS allows simultaneous access to the microphone by two applications, so unless you create a virtual audio device to reroute the audio from two apps, then no, you wouldn't be able to use both at the same time.

If you do create a virtual audio device, you can reroute the audio from the two apps via IRIS Clarity and record its output. This can be done with software such as Loopback or Blackhole.

Note: This is purely an operating system limitation, not an IRIS Clarity limitation.